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Elissa's Fitness | Virtual and In-Home Personal Trainer

Weight Loss Drug Dangers: Why Weight Training Is A Better Option

July 31, 2025

Thin and fit woman holding out the jeans she's wearing showing how much weight she lost.

 

Why Weight Training Beats Weight Loss Drugs for Long-Term Health and Fat Loss.

Weight loss has always been a hot topic, and with the rise of medications like Ozempic and Wegovy, it’s getting even hotter. These GLP-1 receptor agonists were originally created for managing Type 2 diabetes but have quickly become the go-to for people looking to shed pounds fast. And yes, they work. People are dropping significant amounts of weight, seemingly without having to diet or set foot in a gym. Sound to good to be true? If you look deeper it is. There’s a side effect that’s quietly lurking beneath the surface of this rapid weight loss trend-and it’s one that could leave your metabolism sluggish, your strength depleted, and your long-term health at risk: muscle loss.

Let’s break it all down and make the case for why strength training is the smarter, healthier, and more sustainable path to losing fat-and keeping it off for good.

The Weight Loss Drug Boom: What’s Going On?

Ozempic, Wegovy, Mounjaro, and similar drugs work by mimicking a hormone (GLP-1) that helps

regulate appetite and blood sugar levels. These medications make people feel full faster and for longer, reducing cravings and overall calorie intake. Studies show significant weight loss, often in the range of 15-20% of total body weight over time.

Sounds great, but here’s the catch: when people lose weight rapidly and aren’t exercising-especially resistance training, they’re not just losing fat. They’re also losing lean muscle tissue and bone. That’s a big problem.

Muscle: Your Metabolic Goldmine

Muscle isn’t just for bodybuilders. It’s your body’s most metabolically active tissue. That means it burns calories even when you’re at rest. The more muscle you have, the higher your resting metabolic rate (RMR). Now imagine losing a chunk of that muscle mass through rapid, drug-induced weight loss. Sure, the

scale may be moving down, but your metabolism is moving down with it.

Dangers of Losing Muscle:

  • Losing muscle means losing strength. This can lead to injuries. Falls and fractures are the leading cause of death among older adults.
  • Muscle loss can lead to decreased bone density and Osteoporosis.
  • Loss of strength can limit mobility and result in loss of independence.
  • Muscle is the single greatest determiner of metabolic rate, how many calories you burn a day.
  • Remember your heart is a muscle and muscle loss can impact cardiovascular health. 
  • Muscles use blood glucose (sugar) for fuel. Muscle loss may increase insulin resistance which can increase your risk of type 2 diabetes.
  • A higher muscle to fat ratio has been linked to greater longevity in older adults.
  • With all these dangers to your health for quick weight loss here is another risk. Metabolism depends on muscle so losing muscle and lean mass makes it harder to keep the weight off.

In other words, losing weight this way might be setting you up to gain it all back and more.

What the Research Says

A 2023 study published in the journal Obesity found that up to 30-40% of the weight lost from GLP-1 drugs may come from lean mass, including muscle. That’s a significant amount-especially for middle-aged and older adults, who already face age-related muscle loss (sarcopenia). Even worse? That muscle doesn’t just magically return when you stop the drug. If you don’t

intentionally rebuild it with resistance training and proper nutrition, your body composition could become worse than when you started: lower muscle, higher fat, and a sluggish metabolism.

So What’s the Alternative? Strength Training.

Here’s the truth: if your goal is to lose fat, improve your health, and keep the weight off long-term, you need to lift weights.

Strength training helps you:

  • Build and preserve lean muscle mass, even in a calorie deficit.
  • Increase your metabolic rate, so you burn more calories throughout the day.
  •  Improve insulin sensitivity, which reduces your risk of diabetes.
  • Strengthen bones and joints, reducing your risk of injury.
  • Improve mental health, confidence, and overall energy.
  • It’s not just about aesthetics-it’s about aging well, moving well, and living strong.

A well-designed strength training program may include exercises including squats, lunges, pushups, carries, and core work for total-body stability. It would also include weight training with dumbbells and kettlebells. Adding in a TRX suspension trainer is also an amazing addition to add to your strength training regimen. Possibilities are endless. Gaining muscle can be fun and empowering! 2-4 sessions per week, 30-45 minutes each as you build muscle and burn fat, your body composition improves with every move. Remember the key is gaining muscle and losing fat . This is the way to keep fat off and keep muscle and bone for life! Read more on the benefits here: Benefits Of Strength Training.

Let’s Talk About Food

Something I always tell my clients is focus on real food. No fad diets, no quick weight loss plans, just real food. This alone will change your health and your life. I teach my clients to read labels. “Natural Flavors” are not natural! I do cooking classes if they want to learn. I love food and expect most people do! Food is good and we need healthy meals to survive and thrive.  I get tired of the stigma toward food. If can be fun to cook and learn how to make healthy food for you and your family! Just quitting sugar and processed foods alone will help you on your weight loss journey. One step at a time to a healthier life. This is the answer!

The Bottom Line

Drugs like Ozempic and Wegovy might be useful tools in certain situations, especially for those with obesity-related health conditions. But they aren’t a magic bullet-and they come with serious downsides, especially when it comes to muscle loss and long-term sustainability.If your goal is to look better, feel better, and live stronger, strength training is the answer.

So before you hop on this latest prescription trend, ask yourself: Do you want to be lighter, or do you want to be stronger? Do you want to lose weight and keep it off, all while maintaining your muscle mass, or chance all the risks of these drugs? I think the answer is clear. Unfortunately I find some folks don’t want to put in the work. I do get it, we are all busy but our health and lives are at stake. This is why I have committed  40 years of my life to helping people. It’s hard to get started but once you do you may really enjoy it! Feeling alive, more flexible and stronger!

If you need help getting started with strength training please reach out for personalized programs and support that meet you exactly where you are. Your body and your future self will thank you.

 

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Filed Under: Blog, Fitness, Health, Nutrition, Virtual Personal Training, Weight Loss Tagged With: Dangers of weight loss drugs, in home trainer Bloomfield Hills MI, muscle, muscle and metabolism, online fitness trainer, Online personal trainer, Ozempic, Strength Training, virtual fitness, virtual personal trainer, Wegovy, weight loss, Weight loss drugs, weight loss drugs and muscle loss, weight loss with strength training, weight training, weight training for weight loss, women and strength training, Women and Weights, Women's Fitness

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